Genome Editing of Haematopoietic Stem and Progenitor Cells to Uncover Novel Therapeutics for Aplastic Anaemia and Other Bone Marrow Failure Syndromes

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

ML Burr, CE Sparbier, KL Chan, YC Chan, A Kersbergen, EYN Lam, E Azidis-Yates, D Vassiliadis, CC Bell, O Gilan, S Jackson, L Tan, SQ Wong, S Hollizeck, EM Michalak, HV Siddle, MT McCabe, RK Prinjha, GR Guerra, BJ Solomon

2019-10-14

Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 sc..

Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

R Agarwal, YC Chan, CS Tam, T Hunter, D Vassiliadis, CE Teh, R Thijssen, P Yeh, SQ Wong, S Ftouni, EYN Lam, MA Anderson, C Pott, O Gilan, CC Bell, K Knezevic, P Blombery, K Rayeroux, A Zordan, J Li

2019-01-01

Ibrutinib plus venetoclax is a highly effective combination in mantle cell lymphoma. However, strategies to enable the evaluation ..